Litsea Cubeba Essential Oil

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Botanical Name:	Litsea Cubeba
Common name:	Aromatic litsea, May chang
Plant family:	Lauraceae
Genus:	Litsea
Appearance/Color:	Pale yellow to yellow liquid with thin and clear consistency
Odor:	It has a crisp, citrus smell with medium aroma at a top note
Blends With:	Basil, Bay, Black pepper, Cardamom, Cedarwood, Chamomile, Clary sage, Coriander, Cypress, Eucalyptus, Frankincense, Geranium, Ginger, Grapefruit, Juniper, Marjoram, Orange, Palmarosa, Patchouli, Petitgrain, Rosemary, Sandalwood, Tea Tree, Thyme, Vetiver, Ylang-Ylang.
Origin:	China
Source:	Fruits
Method of Extraction:	Steam Distillation

The genus Litsea is predominant in tropical and subtropical regions of India, China, Taiwan, and Japan. The plant possesses medicinal properties and has been traditionally used for curing various gastro-intestinal ailments (e.g., diarrhea, stomachache, indigestion, and gastroenteritis) along with diabetes, edema, cold, arthritis, asthma, and traumatic injury. Besides its medicinal properties, Litsea is known for its essential oil, which has protective action against several bacteria, possesses antioxidant and antiparasitic properties, exerts acute and genetic toxicity as well as cytotoxicity, and can even prevent several cancers. Here we summarize the ethnopharmacological properties, essentials oil, medicinal uses, and health benefits of an indigenous plant of northeast India, emphasizing the profound research to uplift the core and immense potential present in the conventional medicine of the country. This review is intended to provide insights into the gaps in our knowledge that need immediate focus on in-situ conservation strategies of Litsea due to its non-domesticated and dioecious nature, which may be the most viable approach and intense research for the long-term benefits of society and local peoples.

Litsea Cubeba is the botanical name for May Chang, a tree belonging to the Lauraceae family. It bears whitish-yellowish flowers that have a characteristic citrusy fragrance and fruits that resemble peppers. Litsea cubeba, or ‘May Chang,’ is a tree that is native to the Southern region of China, as well as the tropical areas of Southeast Asia such as Indonesia and Taiwan, but varieties of the plant have also been found as far as Australia and South Africa. The tree is very popular in these areas and has been utilized for a variety of reasons for hundreds of years.

DISCLAIMER

The complete range of conditions or methods of use are beyond our control therefore we do not assume any responsibility and expressly disclaim any liability for any use of this product. Information contained herein is believed to be true and accurate however, all statements or suggestions are made without warranty, expressed or implied, regarding accuracy of the information, the hazards connected with the use of the material or the results to be obtained from the use thereof. Compliance with all applicable federal, state, and local laws and local regulations remains the responsibility of the user.

The FDA has not evaluated the statements on this website. No claims are made by Venkatramna Industries as to the medicinal value of any products from vriaroma.com or by us. The information presented here is for educating our customers about the traditional uses of essential oils and is not intended to diagnose, treat, cure, or prevent any disease. You are responsible for understanding the safe application of these products. If you have any questions, please call or email us for further information.

As per NAHA guidelines, New Directions Aromatics (NDA) does not recommend the ingestion of essential oils. It is imperative to consult a medical practitioner before using Essential Oils for therapeutic purposes. Pregnant and nursing women and those taking prescription drugs are especially advised not to use this product without the medical advice of a physician. The oil should always be stored in an area that is inaccessible to children, especially those under the age of 7.

Litsea cubeba is a pioneer herb traditionally utilized in medicine. Different extracts from its plant parts, such as bark, leaf, root, and fruits, have been utilized in traditional Chinese medicines for curing various diseases. The fresh green fruit is used for culinary purposes like salad preparation, chutneys, pickles,

Litsea Cubeba Essential Oil in Pharma

Litsea cubeba encompasses a varied number of structurally diverse biologically active compounds, and their uses in traditional medicines and their various functions. The major groups of compounds include alkaloids, monoterpenes, sesquiterpenes, diterpenes, flavonoids, amides, lignans, steroids, and fatty acids. These compounds have anticancer, anti-inflammatory, antimicrobial, antioxidant, antidiabetic, and anti-HIV properties, and therefore have immense potential for treating various diseases

Essence of Litsea Cubebe Essential Oil

Litsea Cubebe produces odor active compounds while the fruits contain biologically active components that are utilized in various foods as a source of natural ingredients and for flavor.

COMMON USAGE

· Fighting Infections

· Stimulates your mind

· Treat the Fatigue

· Good for Skin and Personal Care

· Combat Athlete’s Foot

· Treats pain and inflammation

· Asthma

· Cures problems with digestion

· Backache

· Muscles Pain

· Arrhythmia

· Regulate Blood Pressure

· Pampers your skin health

· Kills insects and keeps your home fresh and clean

· Allergic

· Bronchitis

· Treat the Nausea

· Headache

Ingredients:

S.No	Key Constituents	Strength (%)
1	Geranial	37.9–40.6
2	Neral	25.5–33.8
3	(þ)-Limonene	8.4–22.6
4	Methyl heptenone	0.5–4.4
5	b-Myrcene	0.5–3.0
6	Linalool	1.2–1.7
7	Geraniol	0.5–1.6
8	Sabinene	0.1–1.6
9	Linalyl acetate	0–1.6
10	a-Pinene	0.8–1.4
11	b-Pinene	0.4–1.2
12	Nerol	0.2–1.1

TOXICOLOGICAL INFORMATION

Safety Summary

· Hazards: Drug interaction; teratogenicity; skin allergy.

· Cautions (all routes): Drugs metabolized by CYP2B6.

Cautions (oral): Diabetes medication, pregnancy.

· Cautions (dermal): Hypersensitive, diseased or damaged skin, children under 2 years of age. Maximum daily oral dose in pregnancy 56 mg

Maximum dermal use level 0.8%

· Safety advice

Recommended maximum dermal use of 0.8% to avoid skin sensitization. This is based on the IFRA maximum for citral of 0.6% for body oils and lotions and 75% citral content. We recommend a daily oral maximum in pregnancy of 56 mg. This is based on 74% citral content, with dermal and oral citral limits of 0.6% and 0.6 mg/kg.

Organ Specific Effects

· Adverse skin reaction:

Undiluted May Chang oil was moderately to markedly irritating to rabbits and was strongly irritating to both mice and pigs; tested at 8% on 25 volunteers it was neither irritating nor sensitizing. It is non-phototoxic. In a study of 200 consecutive dermatitis patients, three were sensitive to 2% May Chang oil on patch testing. Citral can induce sensitization reactions, and this effect can allegedly be reduced by the co-presence of (þ)-limonene. In a mouse local lymph node assay, which allows comparative measuring of skin sensitizing potency, May Chang oil was a weak sensitizer, with a similar potency to citral.

· Cardiovascular effects: Gavage doses of 10, 15 or 20 mg/kg/ day citral for 28 days, dose-dependently lowered plasma insulin levels and increased glucose tolerance in obese rats.

· Reproductive toxicity: Citral is dose-dependently teratogenic because it inhibits retinoic acid synthesis, and this can affect fetal development.

Systemic Effects

· Acute Toxicity: May Chang oil acute oral LD50 in rats >5 g/kg; acute dermal LD50 in rabbits 4.8 g/kg. Tests using both rats and mice resulted in the following approximate values for May Chang oil: acute oral LD50 4.0 g/kg, acute dermal LD50 >5.0 g/kg, inhalation LC50 12,500 ppm.

· Carcinogenic/anti carcinogenic potential: May Chang oil was not geno toxic to Salmonella tymphimurium and did not induce micronuclei in bone marrow cells or chromosome aberrations in mouse spermatocyte cells. Citral, (þ)- limonene, and geraniol display anti carcinogenic activity