Sage Organic Essential oil

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Product Details

Botanical Name:	Salvia officinalis
Common name:	Sage,
Plant family:	Lamiaceae
Genus:	Salvia
Appearance/Color:	A thin, clear, colourless to pale yellow liquid.
Odor:	A top note with a medium aroma, this oil has a warm and woody scent, though sweeter and slightly floral.
Blends With:	Orange, Bergamot, Neroli, LIme, Lemon, Grapefruit, Lavender, Jasmine and Rose.
Origin:	Spain
Source:	Leaves
Method of Extraction:	Steam Distillation

Salvia officinalis commonly called sage, is the culinary sage familiar to most cooks. It also has excellent ornamental qualities, however. Variably called culinary sage, common sage or garden sage, this woody-stemmed, semi-shrubby perennial typically grows 1.5-2.5' tall.

S. officinalis (sage, garden sage, or common sage) is a perennial, evergreen subshrub, with woody stems, grayish leaves, and blue to purplish flowers. It is native to the Mediterranean region, being currently cultivated in various countries. Sage is one of the oldest medicinal plants, and the etymology of the Latin name suggests its healing properties, with Salvia deriving from the Latin verb salvare = to save or to cure, and officinalis also means medicinal.

DISCLAIMER

The complete range of conditions or methods of use are beyond our control therefore we do not assume any responsibility and expressly disclaim any liability for any use of this product. Information contained herein is believed to be true and accurate however, all statements or suggestions are made without warranty, expressed or implied, regarding accuracy of the information, the hazards connected with the use of the material or the results to be obtained from the use thereof. Compliance with all applicable federal, state, and local laws and local regulations remains the responsibility of the user.

The FDA has not evaluated the statements on this website. No claims are made by Venkatramna Industries as to the medicinal value of any products from vriaroma.com or by us. The information presented here is for educating our customers about the traditional uses of essential oils and is not intended to diagnose, treat, cure, or prevent any disease. You are responsible for understanding the safe application of these products. If you have any questions, please call or email us for further information.

As per NAHA guidelines, New Directions Aromatics (NDA) does not recommend the ingestion of essential oils. It is imperative to consult a medical practitioner before using Essential Oils for therapeutic purposes. Pregnant and nursing women and those taking prescription drugs are especially advised not to use this product without the medical advice of a physician. The oil should always be stored in an area that is inaccessible to children, especially those under the age of 7.

Salvia sp. has also been used for a long time in folk medicine as medication against fever, rheumatism, perspiration, sexual debility, and in the treatment of chronic bronchitis, as well as mental and nervous diseases. Salvia officinalis L. (Lamiaceae) is a Mediterranean species, naturalized in many countries. In Jordan, it is used in traditional medicine as antiseptic, antiscabies, antisyphilitic, and anti-inflammatory, being frequently used against skin diseases.

Sage Essential oil in Pharma

Common sage is well known in Palestitian traditional medicine by possessing antimicrobial properties. Essential oil of sage and their preparations are externally used for inflammations and infections of the mucous membranes of throat and mouth (stomatitis, gingivitis, and pharyngitis). Internally, the essential oil is used for dyspeptic symptoms and excessive perspiration.

Essence of Sage Essential oil

Sage is largely used as a savory food flavoring either as dried leaves or essential oil. Sage leaves and its essential oil possess carminative, antispasmodic, antiseptic, astringent, and antihidrotic properties. The predominant medicinally valuable metabolites are monoterpenes (e.g., ?- and ?-thujone, 1,8-cineole, camphor), diterpenes (e.g., carnosic acid) triterpenes (oleanoic and ursolic acids), and phenolic compounds like rosmarinic acid.

COMMON USAGE

· Antifungal

· Antimicrobial

· Antibacterial

· Antioxidant

· Antiseptic

· Anti-inflammatory

· Antispasmodic

· Cholagogue and choleretic

· Cicatrisant

· Depurative

· Digestive

· Disinfectant

· Emmenagogue

· Expectorant

· Laxative

· Stimulant

Ingredients:

S.No	Key Constituents	Strength (%)
1	Camphor	7.3-50.2
2	a-thujone	13.1-48.5
3	borneol	1.5-23.9
4	1,8-cineole	1.8-21.7
5	b-thujone	3.9-19.1
6	b-caryophyllene	0.2-9.7
7	camphene	0-8.6
8	a-pinene	0-8.0
9	Bornyl acetate	0.3-5.7
10	b-pinene	0-1.2

TOXICOLOGICAL INFORMATION

Safety Summary

· Hazards May be neurotoxic, based on camphor content

· Contraindications Should not be taken in oral doses.

· Contraindications (all routes) Pregnancy, breastfeeding.

· Maximum dermal use level 0.4%

Organ Specific Effects

· Adverse skin reactions: Undiluted Dalmatian sage oil was moderately irritating to rabbits; tested at 8% on 25 volunteers it was neither irritating nor sensitizing. A 24-hour patch test using undiluted sage oil produced one irritation reaction in 20 volunteers. A 65-year-old aromatherapist with multiple essential oil sensitivities reacted to both 1% and 5% sage oil.

· Cardiovascular effects: A subcutaneous injection of 39 mg/kg of sage oil caused hypoglycemia in both normal and alloxan-diabetic rats after one hour. In contrast, Eidi et al found no significant change in serum glucose levels in streptozotocin-diabetic rats for up to five hours after ip administration of 0.042, 0.125, 0.2 or 0.4 mL/kg of Dalmatian sage oil.

· Reproductive toxicity: When Dalmatian sage oil (0.25%, 375 mg/kg) was fed to pregnant mice for two weeks, it negatively influenced the distribution of embryos according to nucleus number.

· Neurotoxicity Convulsions appeared for sage oil at over 500 mg/kg ip in rats. A 44-year-old woman who weighed 133 lb died hours after ingesting two easpoons of sage oil as a treatment for asthma Before dying she suffered epileptiform convulsions. Doctors reported cardiac failure and dyspnea, and estimated that she had drunk 0.25 oz. Post-mortem examination showed only slight damage to the stomach and small intestine. The lungs smelled strongly of sage, and were ‘emphysematous’. No other organ showed any sign of damage. In a second case, convulsions occurred in an adult who accidentally ingested one ‘swallow’ of sage oil. In a third case, a 54-year-old woman ingested at least one ‘swallow’ of sage oil. After 30 minutes she suffered a tonic-clonic seizure and remained unconscious for one hour. In a fourth case, a 53- year-old man ingested 12 drops of sage oil. He rapidly developed a tonic-clonic seizure followed by a 15 minute coma. Neurological tests were normal. In three further non-fatal cases, all in Turkey, accidental ingestion of sage oil by a newborn, a 1-month-old boy and a 5 1/2-year-old girl was followed by seizures.

· Hepatotoxicity An essential oil of Salvia officinalis with 17.4% a-thujone, 13.3% a-caryophyllene, 12.7% 1,8-cineole, 8.3% borneol 3.9% b-thujone, 3.3% camphor was tested for toxicity to rat hepatocytes. The oil was not toxic when present at concentrations of 200 nL/mL or less. However at 2,000 nL/mL significant LDH leakage and glutathione decrease occurred, indicating cell damage.

Systemic Effects

· Acute toxicity: Dalmatian sage oil acute oral LD50 in rats reported as 2.6 g/kg both by Opdyke and Von Skramlik acute subcutaneous LD50 in mice 1.95 g/kg acute dermal LD50 in rabbits >5 g/kg.

· Antioxidant/ pro-oxidant activity : Dalmatian sage oil showed high antioxidant activity as a DPPH radical scavenger and against lipid peroxidation.

· Carcinogenic/anticarcinogenic potential: Dalmatian sage oil was not mutagenic in a chromosomal aberration test, a Bacillus subtilis rec-assay or the Ames test. It was similarly non-mutagenic in S. typhimurium strains T98 and T100, with or without S9. Sage oil was not mutagenic in S. typhimurium TA100, and inhibited UV-induced mutations. Dalmatian sage oil was antimutagenic in Salmonella/microsome, E. coli K12, and S. cerevisiae D7 reversion assays. Given orally to mice at 25, 50 or 100 mL/kg, Dalmatian sage oil was not mutagenic at the low dose, but was slightly mutagenic at 50 mL/kg. At 100 mL/kg the oil was cytotoxic. Both of the lower doses inhibited CA induced by mitomycin C. Dalmatian sage oil was active against human melanoma and renal cell adenocarcinoma cell lines in vitro. It was cytotoxic to human oral squamous cell carcinoma cells, with an IC50 of 135 mg/mL.

· Serious eye damage / irritation No additional Data available.

· Respiratory or skin sensitization No additional data available.

· Germ Cell Mutagenicity No additional data available.

· Reproductive toxicity No additional data available.

· STOT-single exposure No additional data available.

· STOT-repeated exposure No additional data available.

· Aspiration hazard: No additional data available.

· Photo-toxicity: No additional data available.